from Hacker News

Autism Has No Single Cause. Here’s How We Know

by hbcondo714 on 9/11/25, 8:22 PM with 17 comments

  • by austin-cheney on 9/11/25, 9:57 PM

    Some forms of autism are highly inheritable. Asperger's Syndrome is inheritable at a rate of about 80%. In these cases the cause is genetic, but genetics is likely only one of many potential causes. '
  • by matznerd on 9/12/25, 12:43 AM

    "A large new study published in the International Journal of Hygiene and Environmental Health provides evidence that exposure to certain workplace chemicals among parents may influence the severity of autism spectrum disorder (ASD) symptoms and contribute to behavioral, cognitive, and adaptive challenges in their children. The findings suggest that occupational exposures—especially to plastics, ethylene oxide, phenols, and pharmaceutical agents—may have broader developmental effects beyond autism diagnosis alone."

    "The effects of parental occupational exposures on autism spectrum disorder severity and skills in cognitive and adaptive domains in children with autism spectrum disorder" https://www.sciencedirect.com/science/article/pii/S143846392...

    The person leading this study, Erin C. McCanlies, was forced out of the CDC, her division eliminated and she went into early retirement from the CDC. https://www.psypost.org/scientist-who-linked-autism-to-chemi...

    ---

    "The findings suggest that workplace exposures to several specific chemical classes were associated with worse outcomes in children with ASD. One of the strongest and most consistent patterns involved plastics and polymer chemicals. Fathers’ exposure to plastics was associated with lower scores across all cognitive and adaptive skill domains, including language, motor coordination, daily living skills, and overall functioning. When both parents were exposed, the deficits appeared to compound.

    “I was surprised how strongly and consistently plastics and polymers stood out as being linked with multiple developmental and behavioral outcomes including irritability, hyperactivity, and daily living,” McCanlies told PsyPost.

    Exposure to ethylene oxide—commonly used in hospital sterilization—was also linked to more severe autism symptoms, lower expressive language abilities, and poorer adaptive functioning. Similarly, parental exposure to phenol (used in construction, automotive, and some consumer products) and pharmaceuticals was associated with increased ASD severity and more pronounced behavioral challenges, especially hyperactivity and stereotyped behavior.

    While the results do not imply that all children exposed to these chemicals will develop more severe symptoms, the patterns suggest that early life exposure to workplace toxicants may amplify certain developmental difficulties in children who already meet criteria for ASD. The study provides one of the most detailed looks to date at how parental occupation may relate not just to diagnosis, but to variation in how autism is expressed.

    “Our findings suggest that certain parental workplace exposures may be related not just to autism, but to worse symptoms and autism behaviors,” McCanlies explained."

  • by esbranson on 9/15/25, 12:27 AM

    > The $1-trillion cuts to Medicaid

    No, that is false. The state Democratic parties are going to cut far, far more.

    > the Trump administration

    You just knew that was coming. My previous statement is unmentioned of course, despite the obviousness of it. That's how propaganda works. Roughly 6-7% of this article.

    > The OBBBA language that cut and restructured Medicaid included explicit exemptions for people classified as "medically frail", which in federal Medicaid law covers people with physical, intellectual, and developmental disabilities.

    Just kidding, we know full well that's not in this article.

    > biology ... genes

    For a article on a medical topic, this article says almost nothing about the underlying biology of autism, at least nothing more than an American Eagle ad. It is really all about that closing, to keep the fire going.

    Propaganda. Sorry I couldn't get to this article sooner, I was editing Wikipedia on healthcare topics, pretty much fighting against everything this article is about.

  • by jdjfjrjje on 9/12/25, 2:33 AM

    Same story with ADHD: the symptoms can be caused by many things.
  • by amai on 9/12/25, 11:13 AM

    I‘m a bit disappointed that the article doesn‘t mention the link between low dopamine and autism. Here is just a recent study:

    https://news.ki.se/new-study-links-dopamine-to-autism-sympto...

    From the study:

    „ This suggests that increased Ca2+ levels can compensate for deficits in β2-nAChR function and restores DA release.“

    Calcium plays an important role here: https://www.stridesaba.com/calciums-role-in-supporting-indiv...

  • by nis0s on 9/11/25, 9:46 PM

    It occurs to me that pain killers can cross the placenta and also affect gut microbes, and that since sometimes autism isn’t inherited, there’s a gut microbe imbalance component to autism that needs more attention, especially related to how gut microbes differ in those born with and without Caesarians. Secondly, how are genes related to autism also linked to the gut-brain axis.

    Gut health isn’t mentioned in the article, so it seems like a good point to bring up.

  • by vnchr on 9/12/25, 12:34 AM

    It’s “settled science.” No need to investigate further. There’s nothing behind the curtain.