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Study: MRI contrast agent causes harmful metal buildup in some patients

by nikolay on 10/24/25, 8:48 PM with 110 comments

https://www.frontiersin.org/journals/toxicology/articles/10....
  • by Neywiny on 10/24/25, 10:37 PM

    This is very interesting to see on here. My mother was the dissenting vote on an FDA panel on this. There are articles about it. I'll copy her words (as reported by something but seems legit)

    > She said that the FDA's plan doesn't go far enough.

    > "It's hard to dismiss an anecdotal report when you are the anecdote. When a patient is finally tested and found to have gadolinium retention, there's no FDA-approved antidote. So what does the patient do?"

    And I want to reiterate that she was "the" no not "a" no. I don't know if her vote alone is what's caused more research into this. But it's probably the thing I brag about her the most. Even though everybody else said it was fine or abstained, she stood strong. If you look up the articles from the time of the panel (2017) you'll see a lot of articles about this panel and how she was the sole no vote. Included in that was a public post from Chuck Norris praising her. He was going to come out to meet us but I think it was a bad Texas hurricane season so that fell through

  • by gclawes on 10/24/25, 9:58 PM

    Every time I've gotten an MRI the doctors and techs have sworn up and down it's impossible for this stuff to stick around. Getting tired of not being able to believe what doctors say...
  • by kyykky on 10/25/25, 8:58 AM

    My kid went to brain MRI because of migraines (standard procedure here for kids to check if there is e.g. a tumor causing the headache). I was pretty nervous due to this kind of research and the preparatory material saying that they might need to use a contrast agent. In the end they didn’t use a contrast agent and I stressed unnecessarily.
  • by hereme888 on 10/24/25, 9:46 PM

    You know what other metal stays in the body, permanently bound to bone and other organs? Bismuth, as in bismuth salycilate, aka Peptobismol. A tiny % actually stays in your body.
  • by bonsai_spool on 10/24/25, 10:57 PM

    This is a poor explanation of an older publication, when the actual new work has a good description:

    https://www.frontiersin.org/journals/toxicology/articles/10....

  • by justinc8687 on 10/25/25, 2:39 AM

    I think the thing to remember with this, as with any kind of medical procedure, is the benefits versus the risks. In many cases, if you're getting this kind of MRI contrast, there's probably a good reason for it. So even if there's some risk, it might be better than say, the cancer or something else they're looking for. I feel like this is something that's often forgot in these discussions.
  • by shakna on 10/24/25, 9:59 PM

    Or to not click through multiple layers of clickbait: https://doi.org/10.1016/j.mri.2025.110383

    Unfortunately, the article isn't much better. It has as an underpinning, a corrected paper: https://doi.org/10.1093/ndt/gfl294

  • by keane on 10/25/25, 6:54 AM

    There's a subreddit, created August 2024, discussing this: https://www.reddit.com/r/GadoliniumToxicity/
  • by anon291 on 10/24/25, 10:24 PM

    The link between NSF and gadolinium-based agents has been known for almost two decades and is common knowledge in the industry.
  • by unsupp0rted on 10/24/25, 10:45 PM

    Nobody told me gadolinium can be retained before I had it the first couple times.

    Like somebody else mentioned, they swore up and down it's perfectly safe.

  • by cjensen on 10/25/25, 12:24 AM

    As someone with CKD and scheduled for an MRI, this was anxiety-inducing.

    The Cleveland Clinic has a good overview[1]. Since there have been no reports of NSF in 15 years, I don't think it's rational to avoid MRIs based on gadolinium retention concerns.

    [1] https://www.ormanager.com/briefs/study-mri-contrast-agent-ca...

  • by RagnarD on 10/25/25, 4:09 AM

    This isn’t newly known, but it’s convenient to stay with the comfortably familiar until the better alternative is forced.
  • by lynx97 on 10/25/25, 7:35 AM

    Great. Only this year, I got roughly 6 doses of gadlinium, and prior to that, I got one every year, going back 20 years. I just recently chatted with a MRI nurse about the fact that I have a bad feeling about getting that stuff so frequently over time, and she dismissed my concerns. They used to remind patients to drink more after the MRI, but even that routine has been ended roughly 5 years ago. Is there anything else I can do except drink more on the day of the injection?
  • by kazishariar on 10/25/25, 1:57 AM

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